Presequences of Mitochondrial Proteins are Recognized through Dynamic Equilibrium Mechanism
نویسندگان
چکیده
منابع مشابه
Tom20 recognizes mitochondrial presequences through dynamic equilibrium among multiple bound states.
Most mitochondrial proteins are synthesized in the cytosol and imported into mitochondria. The N-terminal presequences of mitochondrial-precursor proteins contain a diverse consensus motif (phi chi chi phi phi, phi is hydrophobic and chi is any amino acid), which is recognized by the Tom20 protein on the mitochondrial surface. To reveal the structural basis of the broad selectivity of Tom20, th...
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The discovery that proteins imported from the cytoplasm into mitochondria are usually synthesized as larger precursors (Maccecchini et al., 1979) has focussed attention on the function of targeting sequences in mitochondrial biogenesis. AS protein sorting within a cell is being elucidated, it becomes clear that mitochondria utilize a unique mechanism for the specific targeting and uptake of the...
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Mitochondrial preproteins are transported through the translocase of the outer membrane (TOM) complex. Tim50 and Tim23 then transfer preproteins with N-terminal targeting presequences through the intermembrane space (IMS) across the inner membrane. The crystal structure of the IMS domain of Tim50 [Tim50(164-361)] has previously been determined to 1.83 Å resolution. Here, the crystal structure o...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 2009
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.49.242